Table 1.

List of High-resolution Structures of Cystoviral RdRPs (P2)

PDB	Ligands/Variants	Resolution	Species	Reference
1HI0	5′-dTdTdTdCdC-3′, GTP, Mg2+, Mn2+ (Initiation Complex)	3.0 Å	Φ6	A
1HHS	Mn2+	2.0 Å	Φ6	A
1HHT	5′-dTdTdTdCdC-3′, Mn2+	2.9 Å	Φ6	A
1HI8	Mg2+	2.5 Å	Φ6	A
1HI1	ATP	3.0 Å	Φ6	A
1UVI	5′-UUUUCC-3′, Mn2+	2.15 Å	Φ6	B
1UVJ	5′-UUCC-3′, Mn2+	1.9 Å	Φ6	B
1UVK	5′-GG-3′, Mn2+, Mg2+, pyrophosphate (product state)	2.45 Å	Φ6	B
1UVL	5′-UUUCC-3′, Mn2+	2.0 Å	Φ6	B
1UVM	5′-UUUCC-3′, Mn2+ (alternate conformation)	2.0 Å	Φ6	B
1UVN	5′-UUCC-3′, GTP, Mn2+, Ca2+	3.0 Å	Φ6	B
1WAC	629-QYKW-632/629-SGT-631 mutant	3.0 Å	Φ6	C
2JL9	E491Q mutant	3.2 Å	Φ6	D
2JLF	E491Q mutant, 5′-UUUUCC-3′, Mn2+	3.2 Å	Φ6	D
2JLG	E491Q mutant, 5′-dTdTdTdTdCdC-3′, GTP, Mn2+	2.8 Å	Φ6	D
4A8F	5′-dAdGdCdG-3′, Mg2+, ATP	3.3 Å	Φ6	E
4A8K	5′-dAdAdTdC-3′, Mg2+, GTP	3.5 Å	Φ6	E
4A8M	5′-dAdAdTdC-3′, Mg2+, ATP, GTP	2.92 Å	Φ6	E
4A8O	E634Q mutant, Mn2+	2.67 Å	Φ6	E
4A8Q	E634Q mutant, 5′-dTdTdCdGdCdG-3′, Mg2+, ATP	3.06 Å	Φ6	E
4A8S	E634Q mutant, 5′-dTdTdTdTdCdGdCdGdTdAdGdCdG-3′, Mg2+, ATP	2.9 Å	Φ6	E
4A8W	E634Q mutant, 5′-dTdTdCdGdCdGdTdAdAdGdCdG-3′, Mg2+, ATP	3.04 Å	Φ6	E
4A8Y	E634Q mutant, 5′-dTdTdTdTdCdGdCdGdTdAdAdGdCdG-3′, Mg2+, ATP	3.41 Å	Φ6	E
4B02	Nicked at R607, Mn2+	3.3 Å	Φ6	F
4IEG	Mg2+ (Form A)	2.1 Å	Φ12	G
4GZK	Mg2+ (Form B)	1.69 Å	Φ12	G

A (Butcher et al., 2001), B (Salgado et al., 2004), C (Laurila et al., 2005), D (Poranen et al., 2008c), E (Wright et al., 2012), F (Sarin et al., 2012), G (Ren et al., 2013)