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. Author manuscript; available in PMC: 2009 Sep 15.
Published in final edited form as: J Neurosci. 2008 Dec 24;28(52):14156–14164. doi: 10.1523/JNEUROSCI.4147-08.2008

Figure 1.

Figure 1

Microglia have altered morphology and cluster around amyloid plaques in PDAPP+/−;CX3CR1/GFP+/− mice. 3-D reconstructed z-series stack images taken of cortical microglia in (A) PDAPP+/−;CX3CR1/GFP+/− mice at 3 ½ months of age (in the absence of plaques), in (B) 14 month old PDAPP+/−;CX3CR1/GFP+/− mice around amyloid plaques (blue), in (C) 14 month old PDAPP+/−;CX3CR1/GFP+/− mice in areas lacking plaques, and in (D) 5 month old PDAPP−/−;CX3CR1/GFP+/− mice. GFP labeled microglia are green. Vessels are labeled with Texas-Red dextran. Amyloid fluoresces blue after injection of Methoxy-X04. Scale bar is 20 μm.