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Peripheral m3D6 administration results in marked morphological changes in microglia. 3-D reconstructed z-series stack images taken of 22 month old PDAPP+/−; CX3CR1/GFP+/− mice injected with 500 μg of m3D6 (A–C), an anti-Aβ antibody, or not injected (D–F). GFP labeled microglia are green. Fibrillar amyloid was labeled with Methoxy-X04 (blue). Scale bar is 20 μm.
