CD45 colocalizes with GFP-labeled microglia around amyloid pathology and there is increased staining around plaques following m3D6 administration. Brain sections from 18 month old PDAPP+/−;CX3CR1/GFP+/− mice were stained with CD45 and images were taken at low power (A–H) and high power (I–P). CD45 positive cells are in red (A, E, I, M), GFP labels CX3CR1 positive microglia (B, F, J, N), and Methoxy-X04 labels aggregated amyloid in blue (C, G, K, O). Merged images are also shown (D, G, L, P). Scale bars are 100 μm and 50 μm for low and high power images, respectively.