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. Author manuscript; available in PMC: 2009 Sep 15.
Published in final edited form as: J Neurosci. 2008 Dec 24;28(52):14156–14164. doi: 10.1523/JNEUROSCI.4147-08.2008

Figure 7.

Figure 7

Microglial activation after antibody treatment requires recognition of aggregated Aβ and the Fc domain. (A) The number of microglial processes and (B) the number of microglial cells were counted in 3-D reconstructed z-series stack images in 18 month old PDAPP+/−;CX3CR1/GFP+/− mice not injected (untreated) or injected with 500 μg of m3D6, 500 μg of IgG2b, 500 μg of mHJ5.1, 500 μg of m3D6 Fab fragments. Four mice were studied per treatment group and 6–10 fields of view were imaged in each animal. Data is presented as mean +/− SEM. * p<0.001.