Table 4.
Multivariable-adjusted hemodynamic correlates of brachial and carotid pulse pressures
| Hemodynamic | Total sample (n=3,762) | Non-medicated (n=1,204) | ||||
|---|---|---|---|---|---|---|
| Parameter | Coef. (SE) |
Partial R2 | P-value | Coef. (SE) |
Partial R2 | P-value |
| Brachial pulse pressure | ||||||
| cfPWV | 0.01 (0.0006) |
0.083 | <0.0001 | 0.01 (0.001) |
0.069 | <0.0001 |
| SV index | 2.22 (0.20) |
0.030 | <0.0001 | 1.90 (0.34) |
0.024 | <0.0001 |
| AI | 2.14 (0.20) |
0.030 | <0.0001 | 1.90 (0.33) |
0.026 | <0.0001 |
| LVEF | 0.74 (0.20) |
0.004 | 0.0002 | 0.04 (0.33) |
0.00001 | 0.90 |
| ET | 4.03 (0.18) |
0.112 | <0.0001 | 3.11 (0.33) |
0.063 | <0.0001 |
| UT | −1.31 (0.19) |
0.011 | <0.0001 | −1.29 (0.34) |
0.011 | 0.0001 |
|
| ||||||
| Carotid pulse pressure | ||||||
| cfPWV | 0.01 (0.001) |
0.042 | <0.0001 | 0.014 (0.002) |
0.045 | <0.0001 |
| SV index | 3.51 (0.31) |
0.032 | <0.0001 | 2.73 (0.49) |
0.023 | <0.0001 |
| AI | 2.42 (0.31) |
0.016 | <0.0001 | 2.03 (0.48) |
0.014 | <0.0001 |
| LVEF | 1.38 (0.30) |
0.005 | <0.0001 | 0.45 (0.48) |
0.0007 | 0.36 |
| ET | 6.51 (0.27) |
0.122 | <0.0001 | 5.20 (0.48) |
0.082 | <0.0001 |
| UT | −1.46 (0.30) |
0.006 | <0.0001 | −1.30 (0.49) |
0.005 | 0.008 |
cfPWV=carotid-femoral pulse wave velocity, SV=stroke volume, LVEF=left ventricular ejection fraction, AI=augmentation index, ET=ejection time, UT=upstroke time.
All analyses were adjusted for age, sex, black race, BMI, diabetes, and current smoking status. Coefficients represent change in pulse pressure per 1-SD change in the hemodynamic parameter.