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Use of the DRO to investigate the influence of acquisition and postprocessing strategy on CBV accuracy. CA leakage-corrected (Corr) and -uncorrected (unCorr) CBV percentage error for DSC-MRI simulated at 2 flip angles (FA) and repetition time (TR) values (A–B). For all parameter combinations, CA leakage correction increases CBV accuracy. Leakage-corrected CBV estimates acquired with lower FAs and longer TRs provided more accurate CBV estimates.
