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Effect of RNA and PEG content on the blood circulation time of RNA–SNAs in mice. (A) Increasing PEG content on RNA–SNAs minimizes the adsorption of serum proteins. (B) Circulation of PEGylated RNA–SNAs in mice is extended by increasing PEG loading. Inset shows data plotted on a log scale to highlight the differences in SNA content in the blood at earlier time points.
