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. Author manuscript; available in PMC: 2010 Mar 1.
Published in final edited form as: Cardiovasc Res. 2008 Dec 10;81(4):686–694. doi: 10.1093/cvr/cvn339

Figure 1.

Figure 1

A) Chemical structure of the diphenylurea 1-(3,5-Bis-trifluoromethyl-phenyl)-3-[2,4-dibromo-6-(1H-tetrazol-5-yl)-phenyl]-urea compound, NS5806. B) Action potentials recorded from a canine left ventricular (LV) midmyocardial myocyte before (black) and at 6, 10 and 14 s after 10 μM NS5806 (grey). Basic cycle length (BCL) = 1 s. Representative of n=5. C) Representative Ito currents recorded from isolated LV midmyocardial myocytes in the absence and presence of 10 μM NS5806, n=7. D) Current-voltage (I–V) relation of peak Ito before and after 10 μM NS5806. E) Time constant of decay of Ito before and after 10 μM NS5806. F) Graph showing area under the curve, reflecting the total charge carried by Ito. G) Ito recovery from inactivation using a two pulse protocol. Statistical significance was evaluated by paired t-test.