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. Author manuscript; available in PMC: 2010 Mar 1.
Published in final edited form as: Cardiovasc Res. 2008 Dec 10;81(4):686–694. doi: 10.1093/cvr/cvn339

Figure 2.

Figure 2

Effect of NS5806 on INa and ICaL currents recorded for isolated canine left ventricular (LV) midmyocardial cells and on IKr in endocardial LV myocytes. A) Representative INa traces and average I–V relation recorded before and after 10 μM NS5806 (n=4). B) ICaL currents were elicited by the shown protocol preceded by 5 pre-pulses (from −80 mV to +20 mV for 200 ms) to ensure constant load of the sarcoplasmic reticulum. Representative ICaL traces and average I-V relations recorded before and after 10 μM NS5806 (n=6). C) Representative IKr currents and IKr tail currents measured at −35 mV as a function of voltage at the preceding voltage-step before and after application of 10 μM NS5806 (n=7). D) Representative IK1 recordings in midmyocardial cells (n=8) and the current-voltage relationship at the end of the step protocol before and after application of 10 μM NS5806. Statistical significance was evaluated by paired t-test.