Skip to main content
. Author manuscript; available in PMC: 2010 Mar 1.
Published in final edited form as: Cardiovasc Res. 2008 Dec 10;81(4):686–694. doi: 10.1093/cvr/cvn339

Figure 3.

Figure 3

Effect of NS5806 to induce the electrocardiographic and arrhythmic manifestation of Brugada syndrome in a canine right ventricular wedge preparation paced from the endocardial surface at a BCL of 2 s. A) Endo-and epicardium action potentials and ECG were recorded before and after 5, 10 and 15 μM NS5806, as well as after 30 min of washout. 15 μM NS5806 induce polymorphic ventricular tachycardia (PVT). Representative of n=4. B) 2 mM 4-aminopyrodine (4-AP) blocked Ito and prevented 10 μM NS5806 from increasing the epicardial notch in a left ventricular wedge. Representative of n=4.