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. Author manuscript; available in PMC: 2010 Mar 1.
Published in final edited form as: Cardiovasc Res. 2008 Dec 10;81(4):686–694. doi: 10.1093/cvr/cvn339

Figure 4.

Figure 4

Effect of NS5806 on action potential (AP) parameters recorded from canine right (RV) and left (LV) wedge preparations paced at a BCL of 2 s. Composite data of the effect of NS5806 (0–15 μM) on: A) AP notch magnitude as % of the phase 2 amplitude. B) J-wave amplitude as % of R-wave amplitude. C) Time to peak-plateau in epicardial APs D) Repolarization time measured as action potential duration (APD90) minus time to peak-plateau. E) Superimposed LV epicardial APs recorded in control (black trace) and after 15 μM NS5806 (grey trace). The APs were superimposed at the time of peak of phase 2. n=5–8.