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. Author manuscript; available in PMC: 2017 Oct 18.
Published in final edited form as: JACC Basic Transl Sci. 2017 Apr 24;2(2):212–226. doi: 10.1016/j.jacbts.2016.11.008

Figure 2. Cellular responses to injected biomaterials.

Figure 2

Upon injection of a biomaterial, the resulting cellular responses can largely affect eventual tissue regeneration. Hematoxylin and eosin images are shown for (A) a decellularized myocardial ECM hydrogel (3 days post- injection), (B) acetalated dextran microparticles (7 days post-injection), (C) a methacrylated hyaluronic acid hydrogel (1 day post-injection), (D) a poly(N-isopropylacrylamide)-based synthetic hydrogel (8 weeks post-injection), and (E) an alginate hydrogel (14 days post- injection). (F) Masson’s trichrome staining shows residual alginate in a heart section after 5 weeks post-injection. All tissue sections are from the heart except for (E), which is skeletal muscle. Black arrows, asterisks, and “G” denote the biomaterial. Reproduced with permission from (14,20,23,24,88,89):

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