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. Author manuscript; available in PMC: 2017 Oct 18.
Published in final edited form as: JACC Basic Transl Sci. 2017 Apr 24;2(2):212–226. doi: 10.1016/j.jacbts.2016.11.008

Central Illustration. Acellular biomaterial therapeutics for repairing ischemic damage from MI and PAD.

Central Illustration

Pre-clinical studies have currently been investigating biomaterial-alone therapies or biomaterials loaded with therapeutics as potential treatment options for MI and PAD. Other therapeutics, like miRNAs or exosomes, also show promise as factors to be delivered with a biomaterial. However, the success of these therapies largely depends on satisfying specific design criteria.