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. Author manuscript; available in PMC: 2018 Feb 23.
Published in final edited form as: Cochrane Database Syst Rev. 2017 Feb 23;2:CD010746. doi: 10.1002/14651858.CD010746.pub2

Comparison 4.

Timing comparison: medication before versus medication after

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Intraocular pressure (IOP) increase of ≥ 5 mmHg two to 24 hours after laser trabeculoplasty (LTP) 4 Risk Ratio (M-H, Random, 95% CI) Subtotals only
 1.1 Alpha-2 agonists 4 319 Risk Ratio (M-H, Random, 95% CI) 0.82 [0.25, 2.63]
2 IOP increase of ≥ 10 mmHg two to 24 hours after LTP 4 Risk Ratio (M-H, Random, 95% CI) Subtotals only
 2.1 Alpha-2 agonists 4 319 Risk Ratio (M-H, Random, 95% CI) 1.55 [0.19, 12.43]
3 Mean change in IOP from pre-LTP to measurements taken more than 2 hours but within 24 hours after LTP (mmHg) 3 Mean Difference (Random, 95% CI) Subtotals only
 3.1 Alpha-2 agonists (mmHg) 3 198 Mean Difference (Random, 95% CI) −1.07 [−2.51, 0.37]