Skip to main content
. Author manuscript; available in PMC: 2017 Oct 20.
Published in final edited form as: JACC Basic Transl Sci. 2017 Apr 24;2(2):160–180. doi: 10.1016/j.jacbts.2016.12.002

Figure 1. PP2Ce is an ER membrane targeted protein phosphatase and detected in adult mouse hearts.

Figure 1

A. Schematic description of PP2Ce protein with signal peptide sequence (aa20-40), transmembrane domain, and conserved PP2C phosphatase activity domain highlighted. B. Northern-blot analysis of PP2Ce mRNA expression in different tissues from adult mice with significant expression detected in in brain, heart and diaphragm. C. Immunohistochemistry results displayed PP2Ce (green) was co-localized with SERCA2a (red) in adult rabbit ventricular cardiomyocytes as supported in merged image and line-scanning intensity analysis. D. Relative expression of PP2Ce mRNA detected by qRT- PCR in heart samples from ischemic cardiomyopathy (ICM, n=3) and dilated cardiomyopathy (DCM, n=3) comparing with non-heart failure (normal, n=3). *: p< 0.05 vs. normal.