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. Author manuscript; available in PMC: 2018 May 7.
Published in final edited form as: Mol Psychiatry. 2017 Feb 14;23(5):1213–1225. doi: 10.1038/mp.2017.7

Figure 2.

Figure 2

General behavioral characterization of F4Cre mice. (a) No differences were seen in open-field activity (F4 n =12, F4Cre n =12). (b) An accelerating rotarod test revealed no differences between groups (F4 n = 17, F4Cre n =17). (c) In a 5-day sucrose preference test, the F4Cre mice displayed reduced preference for sucrose solution on the first day than the F4 animals (***P < 0.001), although no other group differences were seen (F4 n =8, F4Cre n =8). (d) No differences were seen in preferences for chocolate food pellets (F4 n =11, F4Cre n =12). (e) Animals from both strains showed a similar significant increase in activity in response to 20 mg kg −1 cocaine (F4 n =12, F4Cre n =12). (f–h) Experimental set-up of conditioned place preference (CPP) experiments (f). No differences were seen in CPPs induced by food (F4 n =8, F4Cre n =7) (g) or 20 mg kg−1 cocaine (F4 n =8, F4Cre n =8) (h). Least preferred side (LPS). (***P < 0.001 and P ≥ 0.05, no significance). All data were presented as mean ±s.e.m. FR, fixed ratio; KO, knockout.