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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Cell Mol Bioeng. 2017 Apr 10;10(5):357–370. doi: 10.1007/s12195-017-0486-7

Figure 1.

Figure 1

Schematic illustrations of (a) polymersomes encapsulating water soluble payloads formed from PEG17-PPS28-PBI-PPS28-PEG17 tetrablock copolymers, and (b) their uptake and degradation by phagocytes. PEG17-PPS28 copolymers were bridged by perylene bisimide (PBI), a hydrophobic dye that emits a red fluorescence when π-stacked within self-assembled membranes. Following endocytosis, disassembly of polymersomes by phagosomal reactive oxygen species (ROS) and pH-activated enzymes disrupts π-π stacking to shift the PBI emission spectrum to a green fluorescence.