Figure 4.
In vitro characterization of PEG17-PPS28-PBI-PPS28-PEG17 polymersomes with RAW 264.7 macrophages. (a) Cytotoxicity of polymersomes after a 48 h incubation with cells. (b) Cellular uptake of polymersomes after a 3 h incubation with cells. (c) Intracellular fluorescence change of polymersome positive (PS+) cells following endocytosis of polymersomes at 50 μg/mL at different time points. PBS was added to control (ctr) cells instead of polymersomes. Statistical significance: *p ≤ 0.1, **p ≤ 0.05, ***p ≤ 0.001.