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. Author manuscript; available in PMC: 2018 Feb 5.
Published in final edited form as: Hepatol Commun. 2017 Apr 1;1(2):153–167. doi: 10.1002/hep4.1027

Figure 3. LKB1 and PTEN synergistically regulates p21 expression.

Figure 3

A. Introduction of shLkb1 to knockdown LKB1 leads to synergistic downregulation of p21 expression with PTEN loss. CON, wild type mouse embryonic fibroblasts mEFs; PKO, Pten null mEFs. n=3.a, different from CON; b, different from CON+shLkb1; c. different from PKO. p<0.05. Data expressed as Mean±SEM. B. Gross phenotype of 3 week old mice lacking LKB1 in control and Pten null livers. CON, Alb-Cre−; LKO, Lkb1loxP/loxP; Alb-Cre+; LPKO, Lkb1loxP/loxP; PtenloxP/loxP; Alb-Cre+. PKO, PtenloxP/loxP; Alb-Cre+. C. Synergistic regulation of p21 by PTEN and LKB1 loss in liver lysates isolated from the respective mouse models. Numbers below the gel image are densitometry quantification of the image shown.