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(A) Co-crystal structure of SETD2 in complex with SAH (PDB ID: 4H12). SET domain (light orange), N-SET domain (light blue), pre-SET domain (cyan), and post-SET motif (red) are highlighted. (B) The SAH binding pocket between SET and Post-SET domains of SETD2. (C) Co-crystal structure of SETD2 in complex with Pr-SNF (PDB ID: 4FMU). (D) The key residues stabilizing the alternative configuration of the post-SET loop and interacting with Pr-SNF’s N-propyl chain.
