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. Author manuscript; available in PMC: 2018 Feb 20.
Published in final edited form as: Chem Rev. 2017 Mar 24;118(3):989–1068. doi: 10.1021/acs.chemrev.6b00801

Figure 24.

Figure 24

(A) Structures of PRMT3 inhibitors 11, 12, and 13. (B) Key interactions of 11 with PRMT3 allosteric pocket (3SMQ). (C) Structure of SGC707. (D) Co-crystal structure of PRMT3 in complex with SGC707 (PDB ID: 4RYL).