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. Author manuscript; available in PMC: 2018 Feb 20.
Published in final edited form as: Chem Rev. 2017 Mar 24;118(3):989–1068. doi: 10.1021/acs.chemrev.6b00801

Figure 7.

Figure 7

(A) X-ray structure of Ct-PRC2 complex (PDB ID: 5CH1). (B) Co-crystal structure of PRC2 with a derivative of CPI-1205 (PDB ID: 5LS6). The key residues and interactions are indicated. SAH (blue) is overlaid for reference (PDB ID: 5HYN). Hydrogen bonds are represented as yellow dashed lines.