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. Author manuscript; available in PMC: 2017 Dec 28.

Published in final edited form as: Infect Genet Evol. 2014 Mar 22;24:127–139. doi: 10.1016/j.meegid.2014.03.011

Table 5.

Overall performance of BNC’s for different ORF1-domains.

Domain	HEV3			HEV4

	Protein sites^a	F-measure Swine/ Human	CA^b (%)	Protein sites^a	F-measure Swine/ Human	CA^b (%)
Mt	70, 81, 89, 129, 137, 141, 151, 152, 158, 161, 189, 192, 200 and 206	0.51/0.72	64.6	61, 72, 75, 89, 122, 139, 148, 150, 189 and 204	0.0/0.83	70.9
Y	219, 240, 246, 248, 302, 323, 355, 363, 393, 399 and 400	0.29/0.75	63.1	239, 248, 274, 277, 304, 306, 332, 335, 338, 340, 356, 357, 359, 363, 413, 423, 428 and 429	0.56/0.87	80.0
Plp	468, 495, 502, 509, 512, 514, 517, 530, 542, 557 and 589	0.69/0.77	73.8	462, 546, 560, 562 and 574	0.79/0.91	87.3
Pp	719, 720, 724, 728, 740, 749, 764, 775, 783, 790, 791, 795 and 797	0.83/0.86	84.6	707, 718, 732, 733, 742, 756, 760, 767, 772 and 779	0.77/0.90	85.5
Md	843, 855, 873, 876, 879, 914, 915, 941, 949, 959, 972, 985 and 992	0.52/0.77	69.2	803, 804, 811, 817, 835, 836, 846, 869, 874, 876, 902, 942 and 952	0.31/1.0	80.0
Hel	1016, 1024, 1043, 1076, 1101, 1146, 1160, 1233, 1234 and 1242	0.59/0.72	66.2	977, 981, 983, 984, 1003, 1007, 1044, 1047, 1064, 1094, 1096, 1100, 1117, 1120, 1124, 1136 and 1196	0.64/0.88	81.8
Pol	1370, 1285, 1508, 1599, 1732, 1386, 1612, 1283, 1481, 1533, 1746, 1426, 1652, 1499, 1638 and 1555	0.79/0.83	81.5	1235, 1236, 1247, 1266, 1303, 1355, 1360, 1447, 1456, 1572, 1632, 1648, 1652, 1692, 1693 and 1704	0.67/0.89	83.6

^a

Site numbering based on polyprotein positions.

^b

Overall classification accuracy of classification by 10-fold CV.