Table 2.

Odds ratios (OR) (95% CI) for VTE according to tertiles of plasma GlcCer levels.

	GlcCer tertiles
Scripps VTE registry	lowest	middle	highest
GlcCer levels (μg/mL)	< 5.3	≥ 5.3 and < 6.5	≥ 6.5
Adjustment
I. none	3.9 (1.9–7.8)	1.1 (0.50–2.5)	1
II. FV Leiden, prothrombin G20210A, BMI, Age, Sex	3.2 (1.5–6.7)	1.1 (0.45–2.6)	1
III. model II plus HDL-C, LDL-C	4.6 (2.0–11)	1.4 (0.52–3.8)	1
IV. model II plus HDL particles, LDL particles	2.8 (1.3–6.2)	0.90 (0.34–2.4)	1
Valencia VTE Registry*	lowest	middle	highest
GlcCer levels (μg/mL)	< 5.4	≥ 5.4 and < 6.6	≥ 6.6
Adjustment
I. none	1.8 (1.2–2.6)	1.3 (0.86–2.0)	1
II. BMI, Age, Sex	1.8 (1.2–2.7)	1.4 (0.93–2.1)	1

The tertile-based odds ratios (OR) (95% CI) for VTE based on the plasma GlcCer levels in controls are shown. Tertile cut points were defined in controls. The subjects with the highest tertile of GlcCer served as reference. Models II to IV were adjusted by variables indicated in the Table. BMI, HDL-C, HDL particles, LDL-C and LDL particles were used as continuous variables.

^*The carriers of FV Leiden and/or prothrombin G20210A and the hormone and/or anticoagulant users were excluded from the subjects available for GlcCer analysis for the Valencia VTE Registry study.