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. Author manuscript; available in PMC: 2017 Aug 3.
Published in final edited form as: J Endocr Soc. 2017 Mar 24;1(5):385–395. doi: 10.1210/js.2017-00081

Figure 3.

Figure 3

The frequency of Nkx6.1-positive nuclei in CPHN cells in the pancreas is comparable in children with and without T1D and is lower than in adults with T1D. Representative images of CPHN and NKx6.1 staining in the pancreas of (a) a child ND donor and (b) a child T1D donor. Individual layers stained for ChrgA (green), endocrine cocktail (insulin, glucagon, somatostatin, pancreatic polypeptide and ghrelin: white), NKx6.1 (red), and DAPI (blue) are shown along with the merged image. Yellow arrows indicate CPHN cells. (c) Comparison of NKx6.1-positive CPHN cells between children and adults (those with and those who were ND) in all compartments of pancreas. Scale bars: 100 μm for lower-power images and 25 μm for insets.