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. Author manuscript; available in PMC: 2017 Aug 3.
Published in final edited form as: J Endocr Soc. 2017 Mar 24;1(5):385–395. doi: 10.1210/js.2017-00081

Figure 4.

Figure 4

The frequency of Nkx2.2-positive nuclei in CPHN cells in the pancreas is comparable in children with and withoutT1D and lower than in adults both with and without T1D. Representative images of CPHN and NKx2.2 staining in the pancreas of (a) a child ND donor and (b) a child T1D donor. Individual layers stained for ChrgA (green), endocrine cocktail (insulin, glucagon, somatostatin, pancreatic polypeptide and ghrelin: white), NKx6.1 (red), and DAPI (blue) are shown along with the merged image. Yellow arrows indicate CPHN cells. (c) Comparison of NKx2.2-positive CPHN cells between children and adults (those with T1D and those who were ND) in all compartments of pancreas. Scale bars are 100 μm for lower-power images and 25 μm for insets.