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. Author manuscript; available in PMC: 2017 Aug 3.
Published in final edited form as: J Dev Biol. 2016 Sep 29;4(4):29. doi: 10.3390/jdb4040029

Figure 2.

Figure 2

Abnormal proliferation of cortical progenitors in the E16.5 hGFAPcre/+;Sufufl/fl neocortex; (A,B) Immunofluorescence staining with anti-BrdU showed that after 4 h of BrdU-treatment, BrdU+ cells were greater in the E16.5 hGFAPcre/+;Sufufl/fl neocortex compared to control littermates (A); Boxed areas in (A) showed that this increase was apparent in the SVZ of the E16.5 hGFAPcre/+;Sufufl/fl neocortex (B); Scale bars = 100 μm; CP, cortical plate; BrdU, 5-bromo-2-deoxyuridine (C) Quantification of BrdU+ cells within the VZ were mildly, yet significantly reduced, in the E16.5 hGFAPcre/+;Sufufl/fl neocortex. In contrast, a significant increase in the density of BrdU+ cells were quantified in the SVZ of the E16.5 hGFAPcre/+;Sufufl/fl neocortex compared to controls; * p-value < 0.05, *** p-value < 0.01.