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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: Cancer Immunol Immunother. 2017 Mar 9;66(6):737–751. doi: 10.1007/s00262-017-1965-3

Figure 4.

Figure 4

IL2Rγ-chain cytokines affect the ability of adoptively transferred Th17 cells to control tumor growth. a Depletion of IL-2 and IL-7 decreases efficacy of Th17 adoptive transfer. B6 mice bearing established B16 melanomas received adoptive transfer of 5×105 TRP-1 Th17 cells. The indicated IL2Rγ-chain cytokines were then depleted from the mice and tumor area was measured 3 times per week. Each line represents one mouse. b Survival curves for deaths due to any cause (top) or only deaths attributable to tumor burden (tumor area >400mm2) (bottom), survival data was pooled from 2 independent experiments with a total of 14–16 mice or 8–12 mice per group for all cause and tumor specific mortality respectively, *p<.05, **p<.01, ***p<.001 by log-rank test