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. Author manuscript; available in PMC: 2018 Mar 27.
Published in final edited form as: Gut. 2016 Nov 21;67(2):263–270. doi: 10.1136/gutjnl-2016-312456

Table 3.

Association of the 15Phe variant with IBS

CTRL IBS IBS-C IBS-D IBS-M IBS-D/M
AF AF p Value OR AF p Value OR AF p Value OR AF p Value OR AF p Value OR
Case–control 0.264 0.306 0.0030* 1.26 0.279 0.42 1.09 0.312 0.0082 1.30 0.329 0.0026* 1.41 0.319 0.00051* 1.34
PopCol 0.29 0.417 0.045 1.89 0.400 0.45 1.72 0.409 0.20 1.88 0.556 0.017 3.81 0.475 0.013 2.50
Combined 0.268 0.309 0.0013* 1.27 0.281 0.39 1.10 0.314 0.0052 1.30 0.336 0.00057* 1.46 0.323 0.00012* 1.36
*

p Value significant after Bonferroni correction for multiple comparisons (N=15), considering five traits (IBS, IBS-C, IBD-D, IBS-M and IBS-D/M) in three datasets (case–control cohorts, PopCol and both combined). Significant p Values (<0.05) highlighted in bold italics.

AF, 15Phe allele frequency; CTRL, controls; IBS-C, constipation-predominant IBS; IBS-D, diarrhoea-predominant IBS; IBS-D/M, IBS-D+IBS-M; IBS-M, IBS mixed phenotype; p Value, p Value from logistic regression adjusted for sex and batch (centre).