Fig. 6.

Dovitinib enhances TMZ-induced cytotoxicity. The xCelligence impedance-based real-time cell monitoring over 96 h under low-dose Dov (1 µm) and TMZ (100 µm) demonstrated that Dov plus TMZ combined had increased cytotoxic effects on GB-10 cells and resulted in stunted cell proliferation when compared to either drug alone. TMZ (100 µm) alone only moderately blocked GB cell growth. The column graphs show the cell index (Y-axis) during 24 h, 48 h, and 72 h of exposure averaged from three independent experiments. ***P < 0.001; **P < 0.01; *P < 0.05.