Figure 1. Strategies to target mutant p53 in cancers.

Two approaches have been used to target mutant p53 for cancer treatment. The first approach is to using small molecular compounds to directly target mutant p53 by induction of its degradation or reactivation of its tumor-suppressive transcriptional activity. Several well-studied small molecular compounds are listed in the left part of this figure. The alternative approach is to targeting pathways that are critical for the survival and growth of p53 mutant cancers. Specific molecular targets, including G2/M regulators, kinases and are listed in the right part of this figure.