. Author manuscript; available in PMC: 2018 Sep 12.

Published in final edited form as: Mult Scler. 2017 Aug 2;24(10):1288–1300. doi: 10.1177/1352458517721356

Table 4.

Correlation of DNA methylation in the VMP1/MIR21 locus with patient characteristics

CpG probe^a	Gene^a	RS8070345^b (N=27)		Ly#^c (N=18)		Age^c (N=18)
CpG probe^a	Gene^a	Coeff	P-val	Coeff	P-val	Coeff	P-val
cg16936953	VMP1	−0.0076	0.59	0.0534	0.10	−0.0067	5E-05
cg12054453	VMP1	−0.0061	0.36	0.0178	0.37	−0.0027	3E-03
cg01409343	VMP1	0.0003	0.98	0.0788	0.078	−0.0070	2E-04
cg18942579	VMP1	−0.0013	0.94	0.0510	0.22	−0.0055	6E-03
cg02782634	VMP1	−0.0275	0.32	0.1077	0.12	−0.0096	2E-03
cg14032089	MIR21	−0.0111	0.69	0.0956	0.16	−0.0101	1E-03
cg27023597	MIR21	0.0090	0.67	0.1034	0.039	−0.0077	5E-04
cg04276626	MIR21	−0.0104	0.72	0.0955	0.15	−0.0103	8E-04
cg02515217	MIR21	−0.0162	0.56	0.0582	0.38	−0.0112	4E-04
cg15759721	MIR21	−0.0134	0.61	0.1116	0.082	−0.0086	2E-03
cg07181702	MIR21	−0.0053	0.84	0.0664	0.31	−0.0105	7E-04

CpG probe ID and annotated gene names from 450K arrays.

Coefficients (Coeff) and p-values (P-val) from a linear regression model with the methylation β-score at each CpG site as the outcome and the following predictors: age, sex and genotype at RS8070345 (N=27).

Coefficients (Coeff) and p-values (P-val) from a linear regression model with the methylation β-score at each CpG site as the outcome and the following predictors: age, sex, and lymphocyte count (Ly#) (N=18). P-val < 0.05 are indicated in bold.