. Author manuscript; available in PMC: 2018 Sep 12.

Published in final edited form as: Mult Scler. 2017 Aug 2;24(10):1288–1300. doi: 10.1177/1352458517721356

Table 5.

Correlation of DNA methylation in the VMP1/MIR21 locus with miR-21 and VMP1 expression levels

CpG probe^a	Gene^a	R	miR-21^b (N=27)		P-val	VMP1^b (N=27)
CpG probe^a	Gene^a	R	P-val	Coeff	P-val	R	P-val
cg16936953	VMP1	−0.34	0.083	−3.49	0.14	−0.02	0.91
cg12054453	VMP1	−0.23	0.24	−3.84	0.42	0.02	0.90
cg01409343	VMP1	−0.40	0.038	−3.85	0.054	−0.06	0.77
cg18942579	VMP1	−0.32	0.108	−2.53	0.21	0.09	0.66
cg02782634	VMP1	−0.42	0.027	−2.39	0.042	−0.11	0.57
cg14032089	MIR21	−0.38	0.047	−2.11	0.081	−0.08	0.70
cg27023597	MIR21	−0.35	0.076	−2.50	0.12	0.13	0.52
cg04276626	MIR21	−0.54	0.004	−3.08	0.006	−0.04	0.82
cg02515217	MIR21	−0.43	0.025	−2.82	0.029	0.08	0.68
cg15759721	MIR21	−0.50	0.008	−3.20	0.013	−0.06	0.76
cg07181702	MIR21	−0.51	0.006	−3.32	0.006	−0.04	0.83

CpG probe ID and annotated gene names from 450K arrays.

Pearson’s (R) and regression coefficients (Coeff), with accompanying p-values (P-val), from a Pearson’s correlation test, for relative expression of miR-21 and VMP1, and a linear regression model with the relative expression of miR 21 as the outcome and methylation β-score at each CpG site and age as predictors. P-val < 0.05 are indicated in bold. Analysis was performed in CD4+ T cells from RR-MS, SP-MS and HC.