Table 2.
Unadjusted Scores and Adjusted Difference Scores of BREAST-Q Patient-Reported Outcomes
| BREAST-Q measure | Cohort | Un-adjusted Scores, mean (SD) | Adjusted mean difference (95% CI) a (fat grafted - not fat grafted) | |||||
|---|---|---|---|---|---|---|---|---|
|
|
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| Baseline | One year post-op | Two years post-op | One year post-op | P Value | Two years post-op | P Value | ||
| Satisfaction with breast | Fat grafted | 58.7 (21.5) | 60.1 (16.7) | 65.6 (17.1) | −4.74 (−8.21, −1.28) | 0.008 | −0.68 (−4.42, 3.06) | 0.719 |
| Not fat grafted | 59.2 (22.5) | 66.1 (17.2) | 66.0 (18.3) | |||||
| Psychosocial well-being | Fat grafted | 68.4 (18.7) | 67.2 (19.3) | 73.2 (19.2) | −3.87 (−7.33, −0.40) | 0.029 | −0.59 (−3.92, 2.74) | 0.728 |
| Not fat grafted | 68.8 (18.5) | 73.5 (19.2) | 75.3 (19.1) | |||||
| Physical well-being | Fat grafted | 77.2 (16.0) | 72.5 (13.5) | 74.8 (15.2) | −1.23 (−3.71, 1.25) | 0.330 | −0.50 (−3.36, 2.36) | 0.729 |
| Not fat grafted | 78.4 (14.7) | 76.2 (14.9) | 76.8 (14.9) | |||||
| Sexual well-being | Fat grafted | 55.7 (20.3) | 48.0 (20.5) | 52.8 (20.9) | −5.59 (−9.70, −1.47) | 0.008 | −2.94 (−7.01, 1.12) | 0.154 |
| Not fat grafted | 54.4 (20.9) | 54.7 (21.0) | 55.4 (21.9) | |||||
Abbreviations: SD, standard deviation; CI, confidence interval.
Based on mixed-effects regression models with each PRO measure at one or two years post-op as the dependent variable; Each model included an indicator for fat grafting between year one and two as the primary predictor, and included as covariates baseline PRO, age, BMI, procedure type, laterality, indication for mastectomy, timing of reconstruction, radiation, smoking history, race, ethnicity, prior fat grafting before year 1 PRO measurements, concurrent revision procedure, cancer recurrence, and prior complication; Also included are random intercepts for study sites (hospitals) and an interaction variable between fat grafting and concurrent revision procedures; Analyses were performed and combined using 10 imputed data sets.