Table 1.
Differences in Demographic and Clinical Characteristics Between the Low and High Evening Fatigue Groups
| Characteristic | Total Sample (n=44) Mean (SD) |
Low Evening Fatigue (n=19; 43.2%) Mean (SD) |
High Evening Fatigue (n=25; 56.8%) Mean (SD) |
Statistics |
|---|---|---|---|---|
|
| ||||
| Age (years) | 56.1 (9.5) | 57.3 (7.8) | 55.2 (10.7) | t=0.72, p=.474 |
|
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| Education (years) | 16.4 (2.4) | 15.9 (2.1) | 16.8 (2.5) | t=−1.27, p=.211 |
|
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| Body mass index (kg/m2) | 27.1 (6.4) | 25.4 (3.9) | 28.4 (7.6) | t=−1.64, p=.111 |
|
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| Karnofsky Performance Status score | 80.9 (12.9) | 86.3 (11.6) | 76.8 (12.5) | t=2.58, p=.014 |
|
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| Self-administered Comorbidity Questionnaire score | 5.8 (3.5) | 4.5 (2.8) | 6.8 (3.8) | t=−2.23, p=.031 |
|
| ||||
| Time since diagnosis (years) | 4.6 (7.7) | 5.5 (6.1) | 3.9 (8.8) | U, p=.142 |
|
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| Time since diagnosis (median, years) | 0.45 | 3.75 | 0.37 | |
|
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| Number of prior cancer treatments | 2.1 (1.8) | 2.8 (1.9) | 1.6 (1.5) | t=2.32, p=.025 |
|
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| Number of metastatic sites including lymph node involvement A | 1.6 (1.7) | 2.1 (1.9) | 1.3 (1.4) | t=1.56, p=.128 |
|
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| Number of metastatic sites excluding lymph node involvement | 1.1 (1.4) | 1.4 (1.5) | 0.8 (1.2) | t=1.26, p=.215 |
|
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| LFS evening fatigue score | 5.6 (2.2) | 3.7 (1.7) | 7.1 (1.2) | t=−7.66, p<.001 |
|
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| % (n) | % (n) | % (n) | ||
|
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| Self-reported ethnicity | χ2=4.96, p=.292 | |||
| White | 77.3 (35) | 68.4 (13) | 80.0 (20) | |
| Asian/Pacific Islander | 11.4 (5) | 15.8 (3) | 8.0 (2) | |
| Black Non-Hispanic | 4.5 (2) | 10.5 (2) | 4.0 (1) | |
| Hispanic/Mixed/Other | 6.8 (3) | 5.3 (1) | 8.0 (2) | |
|
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| Married or partnered (% yes) | 72.7 (32) | 84.2 (16) | 64.0 (16) | FE, p=.181 |
|
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| Lives alone (% yes) | 15.9 (7) | 10.5 (2) | 20.0 (5) | FE, p=.680 |
|
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| Currently employed (% yes) | 29.5 (13) | 31.6 (6) | 28.0 (7) | FE, p=1.00 |
|
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| Annual household income | χ2=2.83, p=.419 | |||
| Less than $30,000 | 2.8 (1) | 0.0 (0) | 4.3 (1) | |
| $30,000 to $70,000 | 16.7 (6) | 23.1 (3) | 13.0 (3) | |
| $70,000 to $100,000 | 8.3 (3) | 0.0 (0) | 13.0 (3) | |
| Greater than $100,000 | 72.2 (26) | 76.9 (10) | 69.6 (16) | |
|
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| Exercise on a regular basis (% yes) | 77.3 (34) | 78.9 (15) | 76.0 (19) | FE, p=1.00 |
|
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| Child care responsibilities (% yes) | 28.9 (11) | 17.6 (3) | 38.1 (8) | FE, p=.282 |
|
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| Elder care responsibilities (% yes) | 13.9 (5) | 12.5 (2) | 15.0 (3) | FE, p=1.00 |
|
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| AJCC Status | χ2=1.36, p=.715 | |||
| Stage 0 | 59.1 (26) | 63.2 (12) | 56.0 (14) | |
| Stage I | 4.5 (2) | 5.2 (1) | 4.0 (1) | |
| Stage IIA, IIB | 18.2 (8) | 10.5 (2) | 25.0 (6) | |
| Stage IIA,IIIB,IIIC,IV | 18.2 (8) | 21.1 (4) | 16.7 (4) | |
|
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| Prior cancer treatmentB | χ2=8.58, p=.035 | |||
| No prior treatment | 14.3 (6) | 11.8 (2) | 16.0 (4) | |
| Only surgery, CTX, or RT | 42.9 (18) | 23.5 (4) | 56.0 (14) | |
| Surgery and CTX, or surgery and RT, or CTX and RT | 9.5 (4) | 5.9 (1) | 12.0 (3) | |
| Surgery and CTX and RT | 33.3 (14) | 58.8 (10) | 16.0 (4) | |
|
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| Metastatic sites | χ2=6.99, p=.073 | |||
| No metastasis | 36.4 (16) | 31.6 (6) | 40.0 (10) | |
| Only lymph node metastasis | 20.5 (9) | 15.8 (3) | 24.0 (6) | |
| Only metastatic disease in other sites | 9.1 (4) | 0.0 (0) | 16.0 (4) | |
| Metastatic disease in lymph nodes and other sites | 34.1 (15) | 52.6 (10) | 20.0 (5) | |
A
Total number of metastatic sites evaluated was 9.
B
Post-hoc contrasts failed to reveal the subgroup(s) underlying the differences in prior cancer treatments observed in the high compared to the low evening fatigue groups.
Abbreviations: AJCC = American Joint Committee on Cancer; CTX = chemotherapy; FE = Fisher’s Exact; kg = kilograms; LFS = Lee Fatigue Scale; m2 = meters squared; SD = standard deviation; RT = radiation therapy; U = Mann-Whitney test; χ2 = Chi-square test.