Table 2.

Differentially Expressed Genes

Probe	Symbol	Name	Fold Change	ENTREZ Gene ID	Direction	Padjusted	Primary Role
Limma
ILMN_1 684308	DEFB103B	Defensin, beta 103B (DEFB103B)	0.10	55894	Down	0.0489	I
GenePattern
ILMN_1 873793	Hs.650028	cDNA FLJ25030 fis, clone CBL02631	0.18		Up	<0.0001	U
ILMN_1655418	CAPNS1	Calpain, small subunit 1	0.58	826	Down	<0.0001	I
ILMN_1705605	MGC13005	PREDICTED: Homo sapiens hypothetical protein MGC13005	0.83		Down	<0.0001	U
ILMN_1728799	FBP1	Fructose-1,6-bisphosphatase 1	0.75	2203	Down	<0.0001	M
ILMN_1808821	COMMD9	COMM domain containing 9	0.59	29099	Down	<0.0001	I
ILMN_2398408	TCEAL1	Transcription elongation factor A (SII)-like 1, transcript variant 2	0.18	9338	Down	<0.0001	I/M
ILMN_1653115	ECH1	Enoyl Coenzyme A hydratase 1, peroxisomal	0.46	1891	Down	<0.0001	M
ILMN_1759652	C1orf61	chromosome 1 open reading frame 61	0.16	10485	Down	<0.0001	U
ILMN_1666269	CTSZ	Cathepsin Z	0.77	1522	Down	<0.0001	I
ILMN_2363668	YIF1B	Yip1 interacting factor homolog B (S. cerevisiae), transcript variant 4	0.55	90522	Down	<0.0001	I/M/S
ILMN 1791211	DOK2	Docking protein 2, 56kDa	0.75	9046	Down	<0.0001	I

Abbreviations: Direction = Direction of gene expression in the high as compared to the low evening fatigue group; P_adjusted = Benjamini-Hochberg adjusted p-value; Fold = fold change of the log₂ transformed, background-corrected, quantile-normalized intensity gene expression values in the high as compared to low evening fatigue group.

The primary functional role(s) of a given gene is identified as follows: M = Metabolism, protein synthesis (n=4); I = Immune activation and immune cell replenishment (n=7); S = serotonergic activation (n=1); U = unknown (n=3).