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Peripheral blood memory cytomegalovirus (CMV)- and HIV-1-specific CD8+ T lymphocytes do not express Foxp3 in vivo despite the presence of ongoing viral infection. Peripheral blood mononuclear cells from two HIV-1-infected subjects were stained with peptide/MHC-I tetramers to identify CD8+ T lymphocytes directed against epitopes from CMV or HIV-1 (KF11, IW9, SL9). Foxp3 expression is plotted, and the percentages of Foxp3+tetramer+ CD8+ T lymphocytes are indicated.
