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. Author manuscript; available in PMC: 2009 Feb 17.
Published in final edited form as: AIDS Res Hum Retroviruses. 2008 Aug;24(8):1087–1095. doi: 10.1089/aid.2008.0041

Fig. 5.

Fig. 5

Virus-specific memory CD8+ T lymphocytes efficiently express CD25 and Foxp3 when proliferating in response to cognate epitopes in vitro, with enhancement by interleukin (IL)-2. Peripheral blood mononuclear cells from four persons with HIV-1 and cytomegalovirus (CMV) infection and one with CMV infection were stimulated with peptide epitopes in the absence or presence of added IL-2 and assessed for proliferation and expression of CD25 and Foxp3 as described in Figure 3. (A, B) Representative plots are shown for CMV (A) and HIV-1 (B) epitopes (seven tested). The results were similar for CMV and HIV-1 epitopes across all individuals. (C) Data are summarized across all epitopes and subjects. (D) An overlay of dot plots depicting Foxp3 versus CD25 expression demonstrates the intensity of expression across different conditions for the experiment plotted in panel A.