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. Author manuscript; available in PMC: 2017 Dec 4.
Published in final edited form as: J Med Biol Eng. 2017 Jul 5;37(5):780–789. doi: 10.1007/s40846-017-0257-x

Fig. 4.

Fig. 4

Effects of different anti-arrhythmic agents or channel blockers on the V141M KCNQ1-augmented transmural heterogeneity of APD. At a cycle length of 1000 ms with isoproterenol (ISO) (upper panel), amiodarone, sotalol, quinidine and IKs block (either at 50 or 90% block) all failed to reduce the mutation-augmented transmural heterogeneity of APD (upper panel). Only the IK1 block (with 90% block) improved APD heterogeneity at both long and short cycle lengths under ISO challenge (lower panel)