Fig. 5.

Effects of I_K1 blockade on the pseudo-ECG and QT interval. a Pseudo-ECGs at a cycle length of 1000 ms for WT and V41M KCNQ1 mutation, at baseline and with isoproterenol, and with 90% I_K1 block. b QT interval measurements for each pseudo-ECG are indicated. c QT intervals on the pseudo-ECG are plotted against the cycle length. In the case of V141M, the QT interval was abnormally shortened with ISO; the shortening of the QT interval was corrected by specific I_K1 blockade. ECG electrocardiogram, WT wild type, V141M V141M KCNQ1 mutation