. Author manuscript; available in PMC: 2017 Dec 4.

Published in final edited form as: J Med Biol Eng. 2017 Jul 5;37(5):780–789. doi: 10.1007/s40846-017-0257-x

Table 1.

Computed APD₉₅ and I_Ks for WT and V141M KCNQ1 using the ORd human ventricular model for Endo, Mid, and Epi myocytes

Myocytes	Condition	ORd human ventricular myocyte model [20]
Myocytes	Condition	APD₉₅ (ms)	Peak I_Ks amplitude (pA/pF)	APD₉₅ shortening (ms/%) (V141M V.S. WT)	APD₉₅ shortening (ms/%) (ISO V.S. baseline)
Endo	WT	278.3	0.086
	V141M	168.1	0.973	110.2/39.6
	WT ISO	249.9	0.507		28.4/10.2
	V141M ISO	140.1	1.516	109.8/43.9	28.0/16.7
Mid	WT	344	0.128
	V141M	230.6	1.336	113.4/33.0
	WT ISO	338.9	0.696		5.1/1.5
	V141M ISO	195.7	3.898	143.2/42.3	34.9/15.1
Epi	WT	238.2	0.0695
	V141M	155.5	1.066	82.7/34.7
	WT ISO	231.8	0.648		6.4/2.9
	V141M ISO	128.4	1.565	103.4/44.6	27.1/17.4

Scaling factors for I_Ks conductance: Endo 1.4, Epi 1.4, and Mid 1.0