Cubic spline showing association of galectin-3 with venous thromboembolism incidence in ARIC, 1996 – 2013. High extreme values of galectin-3 (> 40 ng/ml) were excluded (n=26) from the spline analysis. The 25th percentile (12.2ng/mL) was used as reference in a Cox proportional hazards model adjusted for age, sex, and race. The knots were placed at the 5th, 25th, 50th, 75th, 90th, 95th, and 99th percentiles.