. Author manuscript; available in PMC: 2018 Jul 25.

Published in final edited form as: Res Pract Thromb Haemost. 2017 Sep 4;1(2):223–230. doi: 10.1002/rth2.12038

Table 4.

Race-specific incidence rates (95% CI) and hazard ratios (95% CI) of venous thromboembolism in relation to LGALS3 rs4644 genotype, ARIC, 1996 – 2013

Variable	rs4644 genotype			P-trend
Variable	AA	AC	CC	P-trend
Whites
N (%)	1273 (17.0)	3624 (48.4)	2590 (34.6)	–
Mean (SD) Galectin-3 (ng/mL)	11.2 (2.7)	14.0 (3.3)	16.8 (4.3)	<0.0001
VTEs, n	32	122	98	–
Incidence rate^* (95% CI)	1.9 (1.4 – 2.7)	2.6 (2.2 – 3.1)	3.0 (2.4 – 3.6)	–
Hazard ratios	1 (Referent)	1.34 (0.91 – 1.98)	1.52 (1.02 – 2.26)	0.04
Blacks
N (%)	155 (7.7)	804 (39.8)	1063 (52.6)	–
Mean (SD) Galectin-3 (ng/mL)	12.2 (4.4)	14.4 (4.1)	17.6 (8.2)	<0.0001
VTEs, n	8	46	63	–
Incidence rate^* (95% CI)	4.0 (2.0 – 8.0)	4.6 (3.4 – 6.1)	4.7 (3.6 – 6.0)	–
Hazard ratios^†	1 (Referent)	1.19 (0.56 – 2.52)	1.20 (0.57 – 2.51)	0.72

Unadjusted incidence rates and per 1,000 person-years.

^†

Adjusted for 10 principal components of ancestry.