Figure 1.

Hematopoietic cell behavior and dynamics across three adjacent compartments in hematopoiesis. Three cell division processes affect the population size in the focal compartment j (lower part of the figure, middle): (i) Differentiation of one cell in compartment j-1 at rate r_j-1 leads to two new cells in compartment j - upper left. (ii) During self renewal at rate r_j, a cell divides and produces an identical daughter cell -upper middle. (iii) Differentiation at rate r_j into the downstream compartment j+1 implies loss of one cell - upper right. The model parameters are fixed assuming that that any compartment maintains a constant population of cells, such that net cell loss μ from one compartment is replaced by cells from the upstream compartment, λ. The parameter ε governing the intensity of self renewal is estimated as ε≈ 0.85.