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Superposition of neutrophil cycling (solid curve) as predicted by the model with experimental data taken from Hammond et al, 1989 (solid circles). The normal range for neutrophils is 1.9 − 7.0 ×103/mm3. (A) The simulation is for a mutation that appears in compartment j = 21 with a period T = 21 days. In (B) to (D) we show simulations of the cycling frequency due to hypothetical mutations that occur in upstream (j =16) or downstream compartments (j = 25).
