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. Author manuscript; available in PMC: 2010 Jun 1.

Published in final edited form as: Cell Prolif. 2009 Mar 31;42(3):348–363. doi: 10.1111/j.1365-2184.2009.00602.x

Drug retention and mobility are determined by the magnitude of B_p. The fraction of bound drug (A) and the effective mobility (B) are plotted as a function of the total local drug content relative to the number of binding sites for a range of drugs and tissues (Supplemental Data). Drugs are color coded according to their B_p with cold colors (e.g. blue) designating small B_p values. Scaling analysis of the equilibrium concentration of free drug and the effective diffusivity (Appendix A) provides an estimate of the threshold bulk concentration for binding saturation and drug diffusion (C).

Drug retention and mobility are determined by the magnitude of B_p. The fraction of bound drug (A) and the effective mobility (B) are plotted as a function of the total local drug content relative to the number of binding sites for a range of drugs and tissues (Supplemental Data). Drugs are color coded according to their B_p with cold colors (e.g. blue) designating small B_p values. Scaling analysis of the equilibrium concentration of free drug and the effective diffusivity (Appendix A) provides an estimate of the threshold bulk concentration for binding saturation and drug diffusion (C).