Table 2.
Comparison of perfusion and volumetric data for cGM, NAWM and T2h-l between HC, RRMS, and SPMS subjects after adjusting for confounding factors
| Parameter | HC n=19 |
RRMS n=19 |
SPMS n=20 |
RRMS vs HC |
SPMS vs HC |
SPMS vs RRMS |
|
|---|---|---|---|---|---|---|---|
| cGM |
Median (Interquartiles) |
Median (Interquartiles) |
Median (Interquartiles) |
p-value | p-value | p-value | |
| Global volume | 890 (869, 914) | 864 (827, 895) | 673 (646, 697) | 0.10 | 0.0026 | 0.0020 | |
| CBF | 43.20 (33.91, 54.49) | 41.07 (29.85, 55.68) | 34.05 (27.19, 43.68) | <0.0001 | <0.0001 | 0.0011 | |
| CBV | 2.64 (2.02, 3.29) | 2.53 (1.94, 3.37) | 2.40 (1.92, 3.07) | 0.078 | 0.046 | 0.0062 | |
| MTT | 3.77 (3.20, 4.31) | 3.90 (3.32, 4.41) | 4.30 (3.66, 4.99) | 0.0001 | <0.0001 | <0.0001 | |
| NAWM | Global volume | 878 (812, 894) | 818 (738, 850) | 697 (669, 729) | 0.0115 | 0.0011 | 0.0049 |
| CBF | 23.49 (18.69, 27.78) | 21.55 (16.05, 29.50) | 19.54 (16.74, 24.92) | 0.68 | 0.58 | 0.0080 | |
| CBV | 1.59 (1.28, 2.00) | 1.57 (1.17, 2.15) | 1.51 (1.30, 1.98) | 0.89 | 0.16 | 0.0103 | |
| MTT | 4.51 (4.09, 5.10) | 4.62 (4.08, 5.20) | 4.86 (4.28, 5.41) | 0.25 | 0.0005 | 0.0094 | |
| T2h-l | Global volume | 0.00 | 5.4 (1.2, 9.3) | 6.4 (1.0, 10.9) | NA | NA | 0.82 |
| CBF | 0.00 | 12.77 (8.23, 17.24) | 11.15 (8.95, 15.71) | NA | NA | 0.049 | |
| CBV | 0.00 | 0.99 (0, 1.32) | 1.08 (0.83, 1.47) | NA | NA | 0.0026 | |
| MTT | 0.00 | 4.91 (4.00, 5.63) | 5.64 (4.82, 6.30) | NA | NA | 0.43 |
T2h-l: T2-hyperintense lesions. Bonferroni corrected p<0.017 is considered statistically significant. Age was considered as confounding factor for comparing RRMS vs. HC, and SPMS vs. HC; age, EDSS, and disease duration were considered as confounding factors for comparing SPMS vs. RRMS. All volumes are in cm3. CBF ml/100g/m, CBVml/100g, MTT seconds