Table 3.
Lobar GM and WM volume differences in cm3 between HC, RRMS, and SPMS subjects after adjusting for confounding factors
| Parameter | HC (n=19) Median (Interquartiles) |
RRMS (n=19) Median (Interquartiles) |
SPMS (n=20) Median (Interquartiles) |
RRMS vs HC p-value |
SPMS vs HC p-value |
SPMS vs RRMS p-value |
|---|---|---|---|---|---|---|
| Gray Matter | ||||||
| Frontal Lobe | 200.040 (190.352, 167.944) | 199.248 (192.480, 207.896) | 200.352 (193.500, 207.540) | 0.69 | 0.60 | 0.22 |
| Parietal Lobe | 90.296 (83.992, 94.512) | 89.824 (85.048, 95.176) | 93.368 (88.956, 96.352) | 0.72 | 0.03 | 0.095 |
| Temporal Lobe | 122.740 (110.640, 130.560) | 121.336 (114.672, 128.544) | 106.892 (99.432, 112.928) | 0.86 | 0.0044 | 0.0073 |
| Occipital Lobe | 101.088 (98.536, 106.272) | 97.160 (95.728, 102.960) | 72.792 (69.868, 75.196) | 0.10 | 0.0030 | 0.0033 |
| White Matter | ||||||
| Frontal Lobe | 190.568 (170.368, 201.528) | 170.316 (159.520, 189.112) | 146.260 (134.908, 157.136) | <0.0001 | 0.0006 | <0.0001 |
| Parietal Lobe | 101.200 (94.536, 109.152) | 93.272 (84.944, 97.208) | 81.952 (77.736, 87.532) | 0.0001 | 0.0018 | <0.0001 |
| Temporal Lobe | 70.132 (56.648, 79.352) | 68.512 (64.116, 74.016) | 61.208 (51.576, 71.720) | 0.026 | 0.98 | 0.0026 |
| Occipital Lobe | 32.024 (30.248, 35.092) | 29.092 (24.136, 33.768) | 26.864 (23.552, 31.832) | 0.65 | 0.0098 | 0.0003 |
Bonferroni corrected p<0.017 is considered statistically significant. Age was considered as confounding factor for comparing RRMS vs. HC, and SPMS vs. HC; age, EDSS and disease duration were considered as confounding factors for comparing SPMS vs. RRMS. All volumes are in cm3