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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Cell Mol Life Sci. 2017 Sep 16;74(23):4305–4314. doi: 10.1007/s00018-017-2649-z

Figure 2. Contributions of Periostin to IPF pathophysiology.

Figure 2

In IPF, recurrent idiopathic epithelial cell injury results in inflammation. Periostin is highly expressed in the lungs and subsequently leads to TGF-B activation, increased type 1 collagen production, promotes fiber cross linking and enhanced stiffening of the interstitial matrix. Periostin mediates fibroblast to myofibroblast differentiation and studies from animal models support a role for periostin in epithelial to mesenchymal cell transition.